Boron tribromide → HCID 86710793, 화합물

반응식

[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([O:9]C)[C:3]=1[B:11]([OH:13])[OH:12].B(Br)(Br)Br>>[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([OH:9])[C:3]=1[B:11]([OH:12])[OH:13]

참가 물질

반응물 2

HCID 25134Boron tribromide

HCID 56776689B-(2-Fluoro-6-methoxy-3-methylphenyl)boronic acid

생성물 1

HCID 86710793HCID 86710793, 화합물수율 100.1%

반응 조건

온도: 0 °C

실험 절차

A mixture of (2-fluoro-6-methoxy-3-methylphenyl)boronic acid (200 mg, 1.087 mmol) was cooled to 0° C. and BBr3 (0.308 mL, 3.26 mmol) was added. The mixture was then stirred at rt for 2 h. It was then poured into ice and extracted with EtOAc. The organic layer was dried over MgSO4, filtered and concentrated to obtain 185 mg (95%) of the desired product as a white solid. 1H NMR (400 MHz, CDCl3) δ 8.57 (s, 1H), 7.25-7.15 (m, 1H), 6.71-6.61 (m, 1H), 5.76-5.53 (m, 2H), 2.20 (d, J=2.0 Hz, 3H). LCMS (M+23)=193.

후처리

additionIt was then poured into ice
extractionextracted with EtOAc
dry with materialThe organic layer was dried over MgSO4
filtrationfiltered
concentrationconcentrated

출처 및 근거

ORD 기록: ord-c865d765fe6047bba23d5e760475d74e
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08906929B2

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