1-(4-(2-(5-((Azetidin-3-yloxy)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea → N-((6-(7-(6-(3-cyclopropylureido)pyridin-3-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-hydroxy-N-(2-methoxyethyl)acetamide

HRID 1400933노트

반응식

HRID 1400933 반응식
N1CC(OCC2C=CC(C3SC4C(=NC=CC=4OC4C=CC(NC(NC5CC5)=O)=CC=4F)C=3)=NC=2)C1.C([O:40][CH2:41][C:42]([N:44]([CH2:49][C:50]1[CH:51]=[N:52][C:53]([C:56]2[S:64][C:63]3[C:58](=[N:59][CH:60]=[CH:61][C:62]=3[O:65][C:66]3[CH:67]=[N:68][C:69]([NH:72][C:73]([NH:75][CH:76]4[CH2:78][CH2:77]4)=[O:74])=[CH:70][CH:71]=3)[CH:57]=2)=[CH:54][CH:55]=1)[CH2:45][CH2:46][O:47][CH3:48])=[O:43])(=O)C>>[CH:76]1([NH:75][C:73](=[O:74])[NH:72][C:69]2[N:68]=[CH:67][C:66]([O:65][C:62]3[CH:61]=[CH:60][N:59]=[C:58]4[CH:57]=[C:56]([C:53]5[N:52]=[CH:51][C:50]([CH2:49][N:44]([CH2:45][CH2:46][O:47][CH3:48])[C:42](=[O:43])[CH2:41][OH:40])=[CH:55][CH:54]=5)[S:64][C:63]=34)=[CH:71][CH:70]=2)[CH2:77][CH2:78]1

참가 물질

3

반응물 2

HCID 674417991-(4-(2-(5-((Azetidin-3-yloxy)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylureaHCID 674421792-(((6-(7-(6-(3-Cyclopropylureido)pyridin-3-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)(2-methoxyethyl)amino)-2-oxoethyl acetate

생성물 1

HCID 67442923N-((6-(7-(6-(3-cyclopropylureido)pyridin-3-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-hydroxy-N-(2-methoxyethyl)acetamide

실험 절차

Compounds 411-412 (examples 260-261) were prepared in one step by reacting the amine precursor 401 (table 31), similarly to compound 30 (scheme 13). Compound 413 (example 262) was obtained similarly to compound 31 (scheme 13). Compounds 414-415 (examples 263-264) were prepared in two steps by reacting the corresponding amine precursors 402 (table 31) and 405 (scheme 76), similarly to compound 31 (scheme 13).

후처리

  1. customCompounds 411-412 (examples 260-261) were prepared in one step

출처 및 근거

ORD 기록
ord-a3216e3e763e44e0bf44fe58708ef8fa
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906852B2

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