3-Nitro[1,1'-biphenyl]-2-amine → 102877-92-9

HRID 1401118노트

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HRID 1401118 반응식
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>[Fe].CC(O)=O>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

4

반응물 1

HCID 131499333-Nitro[1,1'-biphenyl]-2-amine

생성물 1

HCID 18968019102877-92-9

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

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온도
60 °C

실험 절차

2-Amino-3-nitrobiphenyl d (0.613 g, 2.86 mmol) was purged under nitrogen for 30 minutes then HOAc (5 mL) was added followed by iron powder (0.4895 g, 8.76 mmol). The sample was heated at 60° C. for 30 minutes then HOAc (5 mL) was added. The sample was stirred at 60° C. for 1 hour then poured into ice. The sample was extracted with EtOAc (3×100 mL). The EtOAc extracts were washed with saturated NaHCO3 (3×100 mL. The EtOAc layer was dried over MgSO4, filtered, and concentrated to give 2,3-diaminobiphenyl e (0.439 g, 2.38 mmol, 83%).

후처리

  1. customwas purged under nitrogen for 30 minutes
  2. additionHOAc (5 mL) was added
  3. additionthen poured into ice
  4. extractionThe sample was extracted with EtOAc (3×100 mL)
  5. washThe EtOAc extracts were washed with saturated NaHCO3 (3×100 mL
  6. dry with materialThe EtOAc layer was dried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8eb068e5d8fc4e4081fa55a501164e4d
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08907092B2

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