참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,1-Bis(2,2-dimethylpropoxy)-N,N-dimethylmethanamine | HCID 78623 | — |
| 반응물 | HCID 178496567 | HCID 178496567 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 178496568 | HCID 178496568 | 100% |
반응 단계
5-(8-(((trans)-4-Methoxycyclohexyl)methyl)-7-oxo-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl)-4-methylpicolinamide (0.412 g, 1.00 mmol), dimethylformamide dineopentylacetal (1.5 mL) and tetrahydrofuran (10 mL) were combined and heated at 85° C. for 3 h. Reaction was concentrated under a stream of nitrogen placed in reaction vessel. Crude product was used directly for next step (0.467 g, 1.00 mmol, 100% yield). MS (ESI) m/z 466.6 [M+1]+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08907087B2 |
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| 출처 데이터셋 | uspto-grants-2014_12 |
|---|
| ORD ID | ord-6a4d283a37ec4956b9c8ff36ed9b27b1 |
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| 출처 메모 | uspto-grants-2014_12 |
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