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Triethylamine → HCID 53311622, 화합물

HRID 1401801
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HRID 1401801 반응식
[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2.[CH2:26]([O:28][C:29](=[O:40])[CH:30]([CH2:36][CH2:37][CH2:38]Cl)[C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH3:27].C(N(CC)CC)C>CN1C(=O)CCC1>[CH2:26]([O:28][C:29](=[O:40])[CH:30]([CH2:36][CH2:37][CH2:38][N:22]1[CH2:21][CH2:20][N:19]([C:16]2[S:17][CH:18]=[C:14]([C:6]3[CH:5]=[CH:4][C:3]4[C:2]([CH3:25])([CH3:1])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]=4[CH:7]=3)[N:15]=2)[CH2:24][CH2:23]1)[C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH3:27]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 140413Malonic acid, 3-chloropropyl-, diethyl esterHCID 53312286HCID 53312286, 화합물

생성물 1

HCID 53311622HCID 53311622, 화합물

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
100 °C

실험 절차

200 mg (0.53 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazine were dissolved in 5 ml of NMP, 235 μl (1.06 mmol) of 2-(3-chloropropyl)malonic acid diethyl ester and 220 μl (1.59 mmol) of triethylamine were added, and the mixture was stirred at 100° C. overnight. The reaction mixture was evaporated to dryness and purified by means of preparative HPLC. The product is in the form of the TFA salt.

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. custompurified by means of preparative HPLC

출처 및 근거

ORD 기록
ord-8a3e153333d6409e8b3cf4b09f85f38c
출처 데이터셋
uspto-grants-2014_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08907098B2

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