2-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one → 4-((2-Hydroxyethyl)-{1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-yl}amino)butan-1-ol

HRID 1401829

반응식

HRID 1401829 반응식
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]([CH3:18])([CH3:17])[C:7]=2[CH:6]=1)=O.[OH:19][CH2:20][CH2:21][CH2:22][CH2:23][N:24]([CH2:34][CH2:35][OH:36])[CH:25]1[CH2:30][CH2:29][N:28]([C:31](=[S:33])[NH2:32])[CH2:27][CH2:26]1>>[OH:36][CH2:35][CH2:34][N:24]([CH:25]1[CH2:26][CH2:27][N:28]([C:31]2[S:33][CH:2]=[C:3]([C:5]3[CH:14]=[CH:13][C:12]4[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]([CH3:18])([CH3:17])[C:7]=4[CH:6]=3)[N:32]=2)[CH2:29][CH2:30]1)[CH2:23][CH2:22][CH2:21][CH2:20][OH:19]

참가 물질

3

반응물 2

HCID 28013372-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-oneHCID 866718264-[(4-Hydroxybutyl)-(2-hydroxyethyl)amino]-piperidine-1-carbothioic acid amide

생성물 1

HCID 673242204-((2-Hydroxyethyl)-{1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-yl}amino)butan-1-ol

실험 절차

The preparation was carried out as already described starting from 800 mg (1.01 mmol) of 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and 452 mg (1.01 mmol) of 4-[(4-hydroxybutyl)-(2-hydroxyethyl)amino]-piperidine-1-carbothioic acid amide from step d. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.

후처리

  1. customThe product was purified by means of preparative HPLC

출처 및 근거

ORD 기록
ord-17a75ff717bf4ee3a8c4c492f9ab8f13
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08907098B2

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