Water → HCID 67323440, 화합물

HRID 1401851노트

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HRID 1401851 반응식
Br[C:2]1[S:3][CH:4]=[C:5]([Br:7])[N:6]=1.Cl.[NH:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]1.C(N(CC)CC)C.O>CN(C=O)C>[Br:7][C:5]1[N:6]=[C:2]([N:9]2[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]2)[S:3][CH:4]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 27632972,4-Dibromo-1,3-thiazoleHCID 30848514-Piperidone hydrochloride

생성물 1

HCID 67323440HCID 67323440, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
80 °C

실험 절차

1 g (4.12 mmol) of 2,4-dibromothiazole was dissolved in 10 ml of DMF, 1.06 g (7.82 mmol) of piperidin-4-one hydrochloride and 2.3 ml (16.47 mmol) of triethylamine were added, and the mixture was stirred at 80° C. for 3 days. The reaction mixture was stirred into 300 ml of water and extracted by shaking with EA. The organic phase was dried over sodium sulfate, filtered and evaporated. The purification was carried out by means of flash chromatography on silica gel.

후처리

  1. extractionextracted
  2. stirringby shaking with EA
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customThe purification

출처 및 근거

ORD 기록
ord-9a24ae5764b64fbcb5974be2df6fb266
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08907098B2

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