2-Cyanoethanethioamide → [4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]acetonitrile

HRID 1401863

반응식

[C:1]([CH2:3][C:4]([NH2:6])=[S:5])#[N:2].Br[CH2:8][C:9]([C:11]1[CH:20]=[CH:19][C:18]2[C:17]([CH3:22])([CH3:21])[CH2:16][CH2:15][C:14]([CH3:24])([CH3:23])[C:13]=2[CH:12]=1)=O>>[CH3:21][C:17]1([CH3:22])[CH2:16][CH2:15][C:14]([CH3:23])([CH3:24])[C:13]2[CH:12]=[C:11]([C:9]3[N:6]=[C:4]([CH2:3][C:1]#[N:2])[S:5][CH:8]=3)[CH:20]=[CH:19][C:18]1=2

참가 물질

반응물 2

HCID 14162772-Cyanoethanethioamide

HCID 28013372-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one

생성물 1

HCID 2742595[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]acetonitrile

실험 절차

The preparation is carried out as already described starting from 576 mg (5.75 mmol) of 2-cyanothioacetamide and 2 g (4.72 mmol) of 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone.

출처 및 근거

ORD 기록: ord-5607e50b18444811a26f2541da43c652
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08907098B2

연결된 노트

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