Chloromethyl ethyl ether → (NE)-5-chloro-N-[1-(ethoxymethyl)pyrimidin-4-ylidene]-2,4-difluorobenzenesulfonamide
반응식
[Cl:1][C:2]1[C:3]([F:19])=[CH:4][C:5]([F:18])=[C:6]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][N:13]=2)(=[O:10])=[O:9])[CH:7]=1.[CH2:20]([O:22][CH2:23]Cl)[CH3:21]>>[Cl:1][C:2]1[C:3]([F:19])=[CH:4][C:5]([F:18])=[C:6]([S:8](/[N:11]=[C:12]2/[N:13]=[CH:14][N:15]([CH2:23][O:22][CH2:20][CH3:21])[CH:16]=[CH:17]/2)(=[O:9])=[O:10])[CH:7]=1참가 물질
3
실험 절차
Prepared according to the process of Preparation 716 using 5-chloro-2,4-difluoro-N-pyrimidin-4-ylbenzenesulfonamide, Preparation 723 and chloromethyl ethyl ether. The product was a mixture of three regioisomers that were not separated and used in subsequent reactions as a mixture.
후처리
- customPrepared
- additiona mixture of three regioisomers that
- customwere not separated