Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 14025생성일: 2026년 10월 25일
Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → N1-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(cyanomethyl)-N3,N3-dipropylisophthalamide
https://huagongshe.com/reaction/14025
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | 3-Carbamoyl-5-dipropylcarbamoyl-benzoic acid | HCID 22394891 | — |
| 반응물 | (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol Trifluoroacetate | HCID 69869154 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N1-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(cyanomethyl)-N3,N3-dipropylisophthalamide | HCID 44426035 | — |
반응 단계
A mixture of 3-(cyanomethyl)-5-[(dipropylamino)carbonyl]benzoic acid (IX, 0.13 g), (2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]-4-phenyl-2-butanol (VIII, 0.14 g), HATU (0.17 g), and dichloromethane (10 mL) is stirred at 40 degrees C. overnight. After cooling, the mixture is washed with water and the organic phase is separated and dried over magnesium sulfate and taken to dryness under reduced pressure. Chromatography (silica gel) gives the title compound, M+H=571.2
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07727997B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-20201984300a44be9a2d0db57120a64f |
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| 출처 메모 | uspto-grants-2010_06 |
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