3-(4-Chlorophenyl)-1-(2-fluorophenyl)propan-1-one → HCID 131732157, 화합물

반응식

ClC1C=CC(CCC(C2C=CC=CC=2F)=O)=CC=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[F:41])=[CH:29]/[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[F:41])=[CH:29]\[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:22][CH:21]=1

참가 물질

반응물 2

HCID 247260933-(4-Chlorophenyl)-1-(2-fluorophenyl)propan-1-one

HCID 131732158HCID 131732158, 화합물

생성물 1

HCID 131732157HCID 131732157, 화합물

실험 절차

By a procedure similar to that of example 1.85.3, starting from 3-(4-chlorophenyl)-1-(2-fluorophenyl)propan-1-one, (Z)-ethyl 5-(4-chlorophenyl)-3-(2-fluorophenyl)pent-2-enoate and (E)-ethyl 5-(4-chlorophenyl)-3-(2-fluorophenyl)pent-2-enoate were obtained as colourless oils.

출처 및 근거

ORD 기록: ord-89a65f5a302b4897b143679febbc7217
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08912186B2

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