Diisopropylethylamine → (S)-methyl 3-(methyl(1-phenylethyl)amino)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate

참여 물질

역할	이름	HCID	투입량
반응물	Diisopropylethylamine	HCID 81531	—
반응물	(S)-(-)-N,alpha-Dimethylbenzylamine	HCID 2060073	—
반응물	Methyl 3-chloro-2-oxo-1,2-dihydroquinoxaline-6-carboxylate	HCID 68194304	—
용매	Dimethyl Sulfoxide	HCID 679	—
생성물	(S)-methyl 3-(methyl(1-phenylethyl)amino)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate	HCID 70665101	76%

반응 조건

온도	85 °C

반응 단계

To a solution of methyl 3-chloro-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (300 mg, 1.26 mmol) in DMSO (2 mL) was added DIEA (244 mg, 1.89 mmol), and (S)—N-methyl-1-phenylethanamine (204 mg, 1.51 mmol) with stirring for 3 h at 85° C. in an oil bath. The reaction was then quenched by the addition of water (50 mL). The product was precipitated via the addition of water and collected by filtration to give (S)-methyl 3-(methyl(1-phenylethyl)amino)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate as a gray solid (323 mg, 76%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08912188B2
출처 데이터셋	uspto-grants-2014_12
ORD ID	ord-3702cf14e452483791e5b55a8a460e36
출처 메모	uspto-grants-2014_12