Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (1-Benzyl-1H-indazol-5-yl)-(6-bromoquinazolin-4-yl)amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(Phenylmethyl)-1H-indazol-5-amine | HCID 212069 | — |
| 반응물 | 6-Bromo-4-chloro-quinazoline | HCID 16770310 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (1-Benzyl-1H-indazol-5-yl)-(6-bromoquinazolin-4-yl)amine | HCID 21951963 | 83.4% |
반응 단계
Prepared according to Procedure A from 6-bromo-4-chloroquinazoline (5.0 g) and 5-amino-1-benzyl-1H-indazole (5.0 g) in acetonitrile (100 ml) at 100° C. The resulting precipitate was treated with triethylamine in ethyl acetate and water to give the title compound as a yellow solid, (7.37 g); δ H [2H6]-DMSO 9.93 (1H, s), 8.82 (1H, d), 8.52 (1H, s), 8.19 (1H, s), 8.09 (1H, s), 7.92 (1H, dd), 7.65 (3H, m), 7.25 (5H, m), 5.62 (2H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08912205B2 |
| 출처 데이터셋 | uspto-grants-2014_12 |
| ORD ID | ord-abe543ad5d7b487abb4a667907be23bc |
| 출처 메모 | uspto-grants-2014_12 |