(4-Bromophenyl)boronic acid → HCID 90406588, 화합물

HRID 1404166

반응식

HRID 1404166 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:7]=[CH:6][NH:5][C:4]=1[C:8]([O:10][CH3:11])=O.[Br:14][C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1.[CH3:24][C:25]1[C:30]([CH3:31])=[C:29]([OH:32])[CH:28]=[CH:27][C:26]=1[CH2:33][CH2:34]C(OCC)=O>>[Br:14][C:15]1[CH:20]=[CH:19][C:18]([N:5]2[CH:6]=[CH:7][C:3]([C:2]([F:13])([F:12])[F:1])=[C:4]2[CH2:8][O:10][C:11]2[CH:34]=[CH:33][C:26]([CH2:27][CH2:28][CH2:29][OH:32])=[C:25]([CH3:24])[C:30]=2[CH3:31])=[CH:17][CH:16]=1

참가 물질

4

반응물 3

HCID 79599(4-Bromophenyl)boronic acidHCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 90405535methyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylate

생성물 1

HCID 90406588HCID 90406588, 화합물

실험 절차

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-bromophenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, (c) then reacting the resulting product with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)propanoate according to the procedure in Example 1, Step E, and Example 2.

출처 및 근거

ORD 기록
ord-c8dd5bd5855748349a751e0f021ffaa0
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912227B1

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