Phenylboronic Acid → 3-(2,3-Dimethyl-4-{[1-phenyl-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propan-1-ol
반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:7]=[CH:6][NH:5][C:4]=1[C:8]([O:10][CH3:11])=O.[C:14]1(B(O)O)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH3:23][C:24]1[C:29]([CH3:30])=[C:28]([OH:31])[CH:27]=[CH:26][C:25]=1[CH2:32][CH2:33]C(OCC)=O>>[CH3:23][C:24]1[C:29]([CH3:30])=[C:11]([O:10][CH2:8][C:4]2[N:5]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:6]=[CH:7][C:3]=2[C:2]([F:13])([F:12])[F:1])[CH:33]=[CH:32][C:25]=1[CH2:26][CH2:27][CH2:28][OH:31]참가 물질
4
실험 절차
The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and phenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, (c) then reacting the resulting product with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)propanoate according to the procedure in Example 1, Step E, and Example 2.
출처 및 근거
- ORD 기록
- ord-c3769d36aa444669a08c50cd86a55d3a
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08912227B1
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