(4-Methoxyphenyl)boronic acid → 3-(4-{[1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-dimethylphenyl)propan-1-ol

HRID 1404172노트

반응식

HRID 1404172 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:7]=[CH:6][NH:5][C:4]=1[C:8]([O:10][CH3:11])=O.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][CH:17]=1.[CH3:25][C:26]1[C:31]([CH3:32])=[C:30]([OH:33])[CH:29]=[CH:28][C:27]=1[CH2:34][CH2:35]C(OCC)=O>>[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([N:5]2[CH:6]=[CH:7][C:3]([C:2]([F:13])([F:12])[F:1])=[C:4]2[CH2:8][O:10][C:11]2[CH:35]=[CH:34][C:27]([CH2:28][CH2:29][CH2:30][OH:33])=[C:26]([CH3:25])[C:31]=2[CH3:32])=[CH:18][CH:17]=1

참가 물질

4

반응물 3

HCID 201262(4-Methoxyphenyl)boronic acidHCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 90405535methyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylate

생성물 1

HCID 904064053-(4-{[1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-dimethylphenyl)propan-1-ol

실험 절차

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-methoxyphenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, (c) then reacting the resulting product with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)propanoate according to the procedure in Example 1, Step E, and Example 2.

출처 및 근거

ORD 기록
ord-7963facb5826414aaad7ca489ad592d7
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912227B1

반응 노트

불러오는 중…