Thionyl Chloride → 3-Iodo-2-methoxy-benzoyl chloride

반응식

[I:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].S(Cl)([Cl:15])=O>>[I:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([Cl:15])=[O:6]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 121684323-Iodo-2-methoxybenzoic acid

생성물 1

HCID 867229723-Iodo-2-methoxy-benzoyl chloride

반응 조건

온도: 82 °C

실험 절차

To 3-iodo-2-methoxy-benzoic acid (8.29 g, 29.8 mmol) was added thionyl chloride (15 mL). The resulting solution was stirred for 2 minutes then heated to 82° C. and stirred at this temperature for 30 minutes. The solution was then concentrated under reduced pressure to give the title compound. This material was used without further purification.

후처리

stirringstirred at this temperature for 30 minutes
concentrationThe solution was then concentrated under reduced pressure

출처 및 근거

ORD 기록: ord-a0dfb4ece7c749ea94dcf912cc5a2e6c
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08912169B2

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