Ethanolamine → 2-(4-(3-Azidopropylamino)-6-chloro-1,3,5-triazin-2-ylamino)ethanol

HRID 1404416노트

반응식

HRID 1404416 반응식
[CH2:1]([CH2:3][NH2:4])[OH:2].[N:5]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[N:17]=[C:16](Cl)[N:15]=[C:14]([Cl:19])[N:13]=1)=[N+:6]=[N-:7]>CC(C)=O>[N:5]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[N:13]=[C:14]([Cl:19])[N:15]=[C:16]([NH:4][CH2:3][CH2:1][OH:2])[N:17]=1)=[N+:6]=[N-:7]

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 86672179N-(3-azidopropyl)-4,6-dichloro-1,3,5-triazin-2-amine

생성물 1

HCID 866721782-(4-(3-Azidopropylamino)-6-chloro-1,3,5-triazin-2-ylamino)ethanol수율 85%

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

Ethanolamine (2.47 g, 40.4 mmol) in acetone (20 mL) was added to a solution of 1 (2.0 g, 8.1 mmol) in acetone (30 mL). The reaction was stirred at room temperature for 24 hours. The acetone was removed by rotary evaporation and the residue was suspended in CH2Cl2. The mixture was filtered off. The solid collected was washed with CH2Cl2 with H2O and dried under reduced pressure to afford 2 as a white solid (1.86 g, 85%). The product is sufficiently pure for further reactions. ESI-MS m/z 273.1 (M+H+) calculated for C8H14ClN8O 273.1.

후처리

  1. customThe acetone was removed by rotary evaporation
  2. filtrationThe mixture was filtered off
  3. customThe solid collected
  4. washwas washed with CH2Cl2 with H2O
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-e46ae5180b6c47dca94b788e95b4ccbc
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912323B2

반응 노트

불러오는 중…