Ac-430 → HCID 178419998, 화합물

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FC1C=CC([C@@H]([C:10]2[N:19]=[C:18](NC3C=C(C)NN=3)[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)O)=CC=1.FC1C=CC(C(C2N=C([NH:46][C:47]3[CH:51]=[C:50](C)[NH:49][N:48]=3)C3C(=CC=CC=3)N=2)O)=CC=1>>[NH:49]1[CH:50]=[CH:51][C:47]([NH:46][C:10]2[N:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)=[N:48]1

참가 물질

반응물 2

HCID 46892373Ac-430

HCID 56833308(S)-(4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol

생성물 1

HCID 178419998HCID 178419998, 화합물

실험 절차

or an isotopic variant thereof; or pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof. (S)-(4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol was determined to be the (−) isomer of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol by optical rotation analysis.

출처 및 근거

ORD 기록: ord-9f7c51295c4e4bd9b998930d66e06c92
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08912324B2

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