Water → 2-Bromo-4-chloro-6-fluorobenzaldehyde oxime

온도

40 °C

To a solution of 2-bromo-4-chloro-6-fluoro-benzaldehyde (15 g, 63.16 mmol) in 2-propanol (130 ml) was added hydroxyl amine hydrate (50% solution in water, 4.55 g, 68.90 mmol) at 25° C. and the mixture was warmed to 40° C. for 2 h. Water (55 ml) was then added slowly to this mixture and the slurry was aged for 1 h at 20° C. The reaction mixture was filtered and the remaining solid was washed with a mixture of 2-propanol and water (1.5:1) and dried under vacuum to yield the title compound as white solid (12.5 g, 77%).

1. filtrationThe reaction mixture was filtered
2. washthe remaining solid was washed with a mixture of 2-propanol and water (1.5:1)
3. customdried under vacuum

ORD 기록

ord-94e488f15eb24e29825d4bf3c6170d00

출처 데이터셋

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08912221B2