HCID 67959087, 화합물 → 8-(3-Methoxyphenyl)-2-methyl-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine

HRID 1404968노트

반응식

HRID 1404968 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:18]3[O:17][CH:16]([CH3:19])[CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][C:12]=3[S:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1>C(OCC)(=O)C.Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:18]3[O:17][CH:16]([CH3:19])[CH2:15][NH:14][CH2:13][C:12]=3[S:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

3

반응물 1

HCID 67959087HCID 67959087, 화합물

생성물 1

HCID 679591608-(3-Methoxyphenyl)-2-methyl-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine수율 104.5%

시약·촉매·용매 1

HCID 21866389Hydrogen chloride-ethyl acetate용매

실험 절차

tert-Butyl 8-(3-methoxyphenyl)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (287 mg) was stirred in 4 N hydrogen chloride-ethyl acetate solution (5 mL) for 30 min. The reaction solution was concentrated under reduced pressure, and the residue was recrystallized from ethyl acetate to give 8-(3-methoxyphenyl)-2-methyl-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine 1 hydrochloride (220 mg, 92%) as colorless crystals.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-c75567506de947e88348ddd6dc8d14c4
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916549B2

반응 노트

불러오는 중…