{2-[(3-Fluorophenyl)methoxy]phenyl}boronic acid → HCID 66576517, 화합물

HRID 1405189노트

반응식

HRID 1405189 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1.[F:20][C:21]1[CH:22]=[C:23]([CH:35]=[CH:36][CH:37]=1)[CH2:24][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1B(O)O>>[F:20][C:21]1[CH:22]=[C:23]([CH:35]=[CH:36][CH:37]=1)[CH2:24][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1

참가 물질

3

반응물 2

HCID 16218053{2-[(3-Fluorophenyl)methoxy]phenyl}boronic acidHCID 219563434-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

생성물 1

HCID 66576517HCID 66576517, 화합물

실험 절차

Example 26 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and {2-[(3-fluorobenzyl)oxy]phenyl}boronic acid (Aldrich Chemical Company Inc.). The batch was purified by preparative HPLC.

후처리

  1. customExample 26 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-d206671fc88e4abaa1b56fabeae7a13b
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916557B2

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