(2-((2-Chlorobenzyl)oxy)phenyl)boronic acid → HCID 66576518, 화합물

HRID 1405190노트

반응식

HRID 1405190 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1.[Cl:20][C:21]1[CH:37]=[CH:36][CH:35]=[CH:34][C:22]=1[CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1B(O)O>>[Cl:20][C:21]1[CH:37]=[CH:36][CH:35]=[CH:34][C:22]=1[CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1

참가 물질

3

반응물 2

HCID 16217764(2-((2-Chlorobenzyl)oxy)phenyl)boronic acidHCID 219563434-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

생성물 1

HCID 66576518HCID 66576518, 화합물

실험 절차

Example 27 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and {2-[(2-chlorobenzyl)oxy]phenyl}boronic acid (Aldrich Chemical Company Inc.). The batch was purified by preparative HPLC.

후처리

  1. customExample 27 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-c57b3a102b6b45ebab7894b383ef1f62
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916557B2

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