3-Chloroisatoic anhydride → HCID 86723062, 화합물

HRID 1405624

반응식

HRID 1405624 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][C@H:5]1[O:9][C:8](=[O:10])[N:7]([C:11]2[CH:12]=[CH:13][C:14]3[S:19][CH2:18][C:17](=[O:20])[NH:16][C:15]=3[CH:21]=2)[CH2:6]1.[Cl:22][C:23]1[C:28]2[NH:29]C(=O)[O:31][C:32](=O)[C:27]=2[CH:26]=[CH:25][CH:24]=1>>[NH2:29][C:28]1[C:23]([Cl:22])=[CH:24][CH:25]=[CH:26][C:27]=1[C:32]([NH:1][CH2:2][CH2:3][CH2:4][C@H:5]1[O:9][C:8](=[O:10])[N:7]([C:11]2[CH:12]=[CH:13][C:14]3[S:19][CH2:18][C:17](=[O:20])[NH:16][C:15]=3[CH:21]=2)[CH2:6]1)=[O:31]

참가 물질

3

반응물 2

HCID 5175353-Chloroisatoic anhydrideHCID 67303587HCID 67303587, 화합물

생성물 1

HCID 86723062HCID 86723062, 화합물수율 70%

실험 절차

Starting from 6-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one (described in WO 2010/041219) and 8-chloro-1H-benzo[d][1,3]oxazine-2,4-dione and using Procedure A, the title compound was obtained as a colourless solid (97 mg; 70% yield).

출처 및 근거

ORD 기록
ord-ceaf159ad0b1494997a2beba31aa605c
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916573B2

연결된 노트

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