HCID 11608121, 화합물 → HCID 71607630, 화합물

반응식

[C:1]1(=[O:15])[C:10]2[C:5]3=[C:6]([CH2:11][CH2:12][CH2:13][N:4]3[C:3](=[O:14])[NH:2]1)[CH:7]=[CH:8][CH:9]=2.CS(O[CH2:21][CH2:22][CH2:23][C@@H:24]1[O:28][C:27](=[O:29])[N:26]([C:30]2[CH:31]=[CH:32][C:33]3[S:38][CH2:37][C:36](=[O:39])[NH:35][C:34]=3[CH:40]=2)[CH2:25]1)(=O)=O>>[O:29]=[C:27]1[N:26]([C:30]2[CH:31]=[CH:32][C:33]3[S:38][CH2:37][C:36](=[O:39])[NH:35][C:34]=3[CH:40]=2)[CH2:25][C@H:24]([CH2:23][CH2:22][CH2:21][N:2]2[C:1](=[O:15])[C:10]3[C:5]4=[C:6]([CH2:11][CH2:12][CH2:13][N:4]4[C:3]2=[O:14])[CH:7]=[CH:8][CH:9]=3)[O:28]1

참가 물질

반응물 2

HCID 11608121HCID 11608121, 화합물

HCID 86723072HCID 86723072, 화합물

생성물 1

HCID 71607630HCID 71607630, 화합물수율 25%

실험 절차

Starting from 6,7-dihydropyrido[3,2,1-ij]quinazoline-1,3(2H,5H)-dione (prepared according to WO 01/79206) and 6-[(5S)-5-[3-[(methylsulfonyl)oxy]propyl]-2-oxo-3-oxazolidinyl]-2H-1,4-benzothiazin-3(4H)-one (prepared according to WO 2010/041194) and using Procedure E, the title compound was obtained as a colourless solid (48 mg; 25% yield).

출처 및 근거

ORD 기록: ord-f0ed34339e244f5990ab3e8c6d524ab7
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08916573B2

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