9-Biphenyl-4-yl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide → 9-Biphenyl-4-yl-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide

HRID 1405662노트

반응식

HRID 1405662 반응식
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([C:7]2[C:12]3=[N:13][S:14](=[O:18])(=[O:17])[CH2:15][CH2:16][N:11]3[CH:10]=[CH:9][CH:8]=2)=[CH:3][CH:2]=1>C1COCC1.[C].[Pd]>[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:2]=[CH:3][C:4]([CH:7]2[C:12]3=[N:13][S:14](=[O:17])(=[O:18])[CH2:15][CH2:16][N:11]3[CH2:10][CH2:9][CH2:8]2)=[CH:5][CH:6]=1

참가 물질

4

반응물 1

HCID 667489979-Biphenyl-4-yl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide

생성물 1

HCID 667481379-Biphenyl-4-yl-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide수율 104.8%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 10% palladium-carbon (50% wet, 12 mg) and 9-biphenyl-4-yl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (115 mg) in THF (50 mL) was stirred under a hydrogen atmosphere overnight. The reaction mixture was filtered, and the filtrate was concentrated to give the title compound (122 mg) as a white solid. The obtained solid was crystallized from acetonitrile, diisopropyl ether and hexane to give a white solid.

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-a4a40a36f1a54a09a4fbcf0fdac744a0
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916551B2

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