Imidazole → 3-(4-((Tert-butyl(dimethyl)silyl)oxy)phenyl)pyridin-2-amine

HRID 1405808

반응식

HRID 1405808 반응식
[NH2:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:15]([Si:19]([CH3:22])([CH3:21])Cl)([CH3:18])([CH3:17])[CH3:16].N1C=CN=C1.O>CN(C=O)C>[Si:19]([O:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]2[C:2]([NH2:1])=[N:3][CH:4]=[CH:5][CH:6]=2)=[CH:9][CH:10]=1)([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:22])[CH3:21]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 962WaterHCID 28928tert-Butyldimethylsilyl chlorideHCID 667484774-(2-Aminopyridin-3-yl)phenol

생성물 1

HCID 667477073-(4-((Tert-butyl(dimethyl)silyl)oxy)phenyl)pyridin-2-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4-(2-aminopyridin-3-yl)phenol (19.8 g), tert-butyldimethylchlorosilane (21.8 mL) and 1H-imidazol (8.69 g) in DMF (200 mL) was stirred at room temperature for 20 hr. To the mixture was added water, and the resulting precipitate was collected by filtration, and then washed with water to give the title compound (30.5 g) as a white solid.

후처리

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with water

출처 및 근거

ORD 기록
ord-4193a080922a4fcbae0823e6f870bc18
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916551B2

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