5-Formylfuran-2-boronic acid → {cis-5-[4-(Pentafluoro-lambda6-sulfanyl)phenyl]tetrahydrofuran-2-yl}methanol

HRID 1406058노트

반응식

HRID 1406058 반응식
[CH:1]([C:3]1[O:7][C:6](B(O)O)=[CH:5][CH:4]=1)=[O:2].Br[C:12]1[CH:17]=[CH:16][C:15]([S:18]([F:23])([F:22])([F:21])([F:20])[F:19])=[CH:14][CH:13]=1>O.[Ru](=O)=O>[F:19][S:18]([F:20])([F:21])([F:22])([F:23])[C:15]1[CH:14]=[CH:13][C:12]([C@H:6]2[O:7][C@@H:3]([CH2:1][OH:2])[CH2:4][CH2:5]2)=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 27343555-Formylfuran-2-boronic acidHCID 27791941-Bromo-4-(pentafluoro-lambda6-sulfanyl)benzene

생성물 1

HCID 86713723{cis-5-[4-(Pentafluoro-lambda6-sulfanyl)phenyl]tetrahydrofuran-2-yl}methanol

시약·촉매·용매 1

HCID 16211523Ruthenium dioxide hydrate촉매

실험 절차

The requisite {cis-5-[4-(pentafluoro-λ6-sulfanyl)phenyl]tetrahydrofuran-2-yl}methanol was prepared via Suzuki reaction of (5-formylfuran-2-yl)boronic acid with 1-bromo-4-(pentafluoro-λ6-sulfanyl)benzene, followed by hydrogenation in the presence of ruthenium(IV) oxide hydrate.

출처 및 근거

ORD 기록
ord-30b4df5b296d4bc486f4ebee728fc5d0
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916564B2

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