홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → Pyrimidine-5-carboxylic acid-{1-[3-fluoro-4-(4-methoxy-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

HRID 1406337
노트
인쇄 미리보기

반응식

HRID 1406337 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)[CH2:5][NH2:6].[N:19]1[CH:24]=[C:23]([C:25]([NH:27][C:28]2([C:31](O)=[O:32])[CH2:30][CH2:29]2)=[O:26])[CH:22]=[N:21][CH:20]=1.C(N(CC)CC)C>CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)[CH2:5][NH:6][C:31]([C:28]1([NH:27][C:25]([C:23]2[CH:22]=[N:21][CH:20]=[N:19][CH:24]=2)=[O:26])[CH2:30][CH2:29]1)=[O:32]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 289662543-Fluoro-4-(4-methoxy-phenoxy)-benzylamineHCID 594962911-[(Pyrimidine-5-carbonyl)-amino]cyclopropanecarboxylic acid

생성물 1

HCID 25232245Pyrimidine-5-carboxylic acid-{1-[3-fluoro-4-(4-methoxy-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

24.7 mg (0.1 mmol) of 3-fluoro-4-(4-methoxy-phenoxy)-benzylamine were dissolved in 1 ml DMF. 20.7 mg (0.1 mmol) of 1-[(pyrimidine-5-carbonyl)-amino]-cyclopropanecarboxylic acid (prepared in 1b) were also dissolved in DMF and 35.3 mg (0.11 mmol) and 21 μl triethylamine (0.15 mmol) were added. Shaken overnight at ambient temperature and purified by reversed-phase chromatography.

후처리

  1. custompurified by reversed-phase chromatography

출처 및 근거

ORD 기록
ord-343dc22a021f4ef683152d393226b087
출처 데이터셋
uspto-grants-2014_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08916589B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트