Methylamine → Ethyl 2-fluoro-4-(methylamino)-5-nitrobenzoate

HRID 1406449노트

반응식

HRID 1406449 반응식
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8](F)=[CH:7][C:6]=1[F:15])[CH3:2].[CH3:17][NH2:18]>C1COCC1>[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([NH:18][CH3:17])=[CH:7][C:6]=1[F:15])[CH3:2]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 22330120Ethyl 2,4-difluoro-5-nitrobenzoate

생성물 1

HCID 59529818Ethyl 2-fluoro-4-(methylamino)-5-nitrobenzoate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Prepared analogously to example 156b from 2,4-difluoro-5-nitro-benzoic acid ethyl ester and 2 M methylamine solution in THF.

출처 및 근거

ORD 기록
ord-fa8a939dc1a747099abd021578e08324
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916599B2

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