Ethyl 4-amino-2-fluoro-5-nitrobenzoate → Ethyl 4,5-diamino-2-fluorobenzoate

HRID 1406480노트

반응식

HRID 1406480 반응식
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([NH2:14])=[CH:7][C:6]=1[F:15])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([NH2:11])[C:8]([NH2:14])=[CH:7][C:6]=1[F:15])[CH3:2]

참가 물질

4

반응물 1

HCID 59529828Ethyl 4-amino-2-fluoro-5-nitrobenzoate

생성물 1

HCID 67230558Ethyl 4,5-diamino-2-fluorobenzoate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Prepared analogously to example 1b by hydrogenation of 4-amino-5-nitro-2-fluoro-benzoic acid ethyl ester using palladium/charcoal 10% in methanol.

출처 및 근거

ORD 기록
ord-8e42cc9d319c4f1e9ddf91216aa9a661
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916599B2

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