Pyridine → HCID 71680611, 화합물

HRID 1406572노트

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HRID 1406572 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][C:6]=1[F:15])([CH3:4])([CH3:3])[CH3:2].Br[C:17]1[CH:18]=[CH:19][C:20]([N:27]2[C:31]([NH2:32])=[CH:30][C:29]([CH3:33])=[N:28]2)=[C:21]2[C:26]=1[N:25]=[CH:24][CH:23]=[CH:22]2.[N:34]1C=CC=CC=1>>[NH2:34][C:17]1[CH:18]=[CH:19][C:20]([N:27]2[C:31]([NH:32][S:11]([C:8]3[CH:9]=[CH:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[C:6]([F:15])[CH:7]=3)(=[O:13])=[O:12])=[CH:30][C:29]([CH3:33])=[N:28]2)=[C:21]2[C:26]=1[N:25]=[CH:24][CH:23]=[CH:22]2

참가 물질

4

반응물 3

HCID 1049PyridineHCID 848039791452184-05-2HCID 86694542HCID 86694542, 화합물

생성물 1

HCID 71680611HCID 71680611, 화합물수율 62%

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온도
80 °C

실험 절차

A stirring mixture of 4-t-butyl-3-fluorobenzene-1-sulfonyl chloride (prepared from Example 27 step c, 1.1 g, 4.2 mmol) and 1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-amine (0.97 g, 3.2 mmol) in pyridine (5 mL) was heated at 80° C. for 15 h. After cooling to room temperature, the reaction mixture was concentrated in vacuo. The crude solid was recrystallized from hot ethanol (5 mL) and the resulting solid was collected by filtration to give the desired compound (0.10 g, 0.19 mmol, 62%).

후처리

  1. temperatureAfter cooling to room temperature
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. customThe crude solid was recrystallized from hot ethanol (5 mL)
  4. filtrationthe resulting solid was collected by filtration

출처 및 근거

ORD 기록
ord-1ab956b73b0a4aada030e5f198b1a4c9
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916601B2

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