Water → 4-(4-n-Propylphenyl)phenol

HRID 1406837노트

반응식

HRID 1406837 반응식
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16]C)=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].B(Br)(Br)Br.O>ClCCl>[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 25134Boron tribromideHCID 220687594-Methoxy-4′-propylbiphenyl

생성물 1

HCID 136276804-(4-n-Propylphenyl)phenol수율 78.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Then, 21.60 g of 4-(4-propylphenyl)anisole was dissolved in 45 mL of dichloromethane, and the resultant solution was cooled with ice. Then, 35.79 g of boron tribromide was added to the solution at such a rate that the inside temperature did not exceed 10° C., followed by stirring at room temperature for 1 hour. Water was added to separate the mixture into layers, and an organic layer was washed with a saturated aqueous sodium bicarbonate solution and saturated brine and dried by adding sodium sulfate. Then, the solvent was distilled off under reduced pressure, and the residue was recrystallized from ethanol to yield 15.91 g of 4-(4-propylphenyl)phenol.

후처리

  1. customdid not exceed 10° C.
  2. customto separate the mixture into layers
  3. washan organic layer was washed with a saturated aqueous sodium bicarbonate solution and saturated brine
  4. customdried
  5. additionby adding sodium sulfate
  6. distillationThen, the solvent was distilled off under reduced pressure
  7. customthe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-a323e2b0fd784a9cabe0b16f2f690916
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916718B2

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