Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1407237생성일: 2026년 10월 25일
Triethylamine → 3-[1-(3-methylphenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one
https://huagongshe.com/reaction/1407237
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | m-Tolylhydrazinium(1+) chloride | HCID 71562 | — |
| 반응물 | HCID 66710802 | HCID 66710802 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-[1-(3-methylphenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one | HCID 66710696 | 21.2% |
반응 단계
To a solution of 3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one (337 mg, 1.0 mmol) in ethanol (100 mL) were added 3-methylphenylhydrazine hydrochloride (237 mg, 1.5 mmol) and Et3N (0.28 mL, 2.0 mmol). The mixture was stirred at 100° C. for 3 h and the solvent was removed under reduced pressure. Preparative HPLC chromatography provided 3-[1-(3-methylphenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one as a pale yellow solid (84 mg, 21%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08916566B2 |
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| 출처 데이터셋 | uspto-grants-2014_12 |
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| ORD ID | ord-d38b793a13a54396b1ebcca2233569a7 |
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| 출처 메모 | uspto-grants-2014_12 |
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