Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloroisatin → 1-(diphenylmethyl)-6-fluoro-1H-indole-2,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloroisatin | HCID 96047 | — |
| 반응물 | 6-Fluoroisatin | HCID 373905 | — |
| 생성물 | 1-(diphenylmethyl)-6-fluoro-1H-indole-2,3-dione | HCID 67357812 | — |
반응 단계
Following the procedure as described in PREPARATION 4A, and making non-critical variations using 6-fluoroisatin (Sadler, P. W., J. Org. Chem. (1956), 21(2):169-70) to replace 4-chloroisatin, 1-(diphenylmethyl)-6-fluoro-1H-indole-2,3-dione was obtained (76%): mp 167-169° C. (diethyl ether); 1H NMR (300 MHz, DMSO-d6) δ 7.41-7.27 (m, 11H), 6.77 (s, 1H), 6.30-6.26 (m, 1H), 5.82-5.80 (m, 1H); MS (ES+) m/z 354.1 (M+23).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08916580B2 |
| 출처 데이터셋 | uspto-grants-2014_12 |
| ORD ID | ord-6a8f29e0f6d647c09c2228bf8aa72954 |
| 출처 메모 | uspto-grants-2014_12 |