Thionyl Chloride → HCID 58897002, 화합물

HRID 1409109노트

반응식

HRID 1409109 반응식
[C:1]1([CH3:27])[CH:6]=[CH:5][C:4]([S:7]([N:10]2[C:14]3=[N:15][CH:16]=[CH:17][C:18]([C:19]4[CH:20]=[C:21]([CH2:25]O)[CH:22]=[CH:23][CH:24]=4)=[C:13]3[CH:12]=[CH:11]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.S(Cl)([Cl:30])=O>ClCCl>[Cl:30][CH2:25][C:21]1[CH:20]=[C:19]([C:18]2[CH:17]=[CH:16][N:15]=[C:14]3[N:10]([S:7]([C:4]4[CH:5]=[CH:6][C:1]([CH3:27])=[CH:2][CH:3]=4)(=[O:9])=[O:8])[CH:11]=[CH:12][C:13]=23)[CH:24]=[CH:23][CH:22]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 58896939HCID 58896939, 화합물

생성물 1

HCID 58897002HCID 58897002, 화합물수율 99.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (G) (0.25 g, 0.66 mmol) in dichloromethane (5 mL) was added thionyl chloride (0.5 mL, 6.9 mmol) at RT. The solution was allowed to stir until complete as judged by HPLC (1 hour). The solvent was removed under reduced pressure to afford 0.26 g of (H) (99% yield) as a white solid. FIA MS expected for C21H17ClN2O2S: m/e 396.07, found: 396.8 ES+. The material was used without further purification.

후처리

  1. customas judged by HPLC (1 hour)
  2. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-5efb3547f1094afc9081e0d58f457ea9
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921376B2

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