Cyclopentylamine → HCID 58896840, 화합물

HRID 1409115노트

반응식

Br[C:2]1[C:7]([Cl:8])=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.[CH:12]1([NH2:17])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[Cl:8][C:7]1[CH:6]=[N:5][C:4]2[NH:9][CH:10]=[CH:11][C:3]=2[C:2]=1[NH:17][CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

반응물 2

HCID 2906Cyclopentylamine

HCID 468355224-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 58896840HCID 58896840, 화합물

반응 조건

온도: 110 °C

실험 절차

To 4-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine (D) was added cyclopentylamine (0.5 mL) in a sealed tube. The mixture was heated to 110° C. for 24-48 h. The mixture was concentrated. Preparative HPLC provided 5-chloro-N-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-4-amine (127)(7.4 mg) as the TFA salt.

후처리

concentrationThe mixture was concentrated

출처 및 근거

ORD 기록: ord-ad17d807e86648f0bb6d4aae90cacb00
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08921376B2

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