1,2-Dichloroethane → HCID 178513561, 화합물

HRID 1409117노트

반응식

HRID 1409117 반응식
Br[C:2]1[C:7](Cl)=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.C(Cl)CCl.[CH:16]1[CH:17]=C[C:19]2[N:24](O)N=[N:22][C:20]=2[CH:21]=1.CN(C=[O:30])C>>[N:9]1[CH:10]=[CH:11][C:3]2[C:4]=1[NH:5][CH:6]=[CH:7][C:2]=2[C:16]1[CH:21]=[C:20]([C:19]([NH2:24])=[O:30])[NH:22][CH:17]=1

참가 물질

5

반응물 4

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 468355224-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 178513561HCID 178513561, 화합물

실험 절차

To a vial with Compound D′ (0.1 mmol) in DMF (1 mL), EDC (2 equivalent, 0.2 mmol) and HOBt (0.5 equivalent, 0.05 mmol) were added and the reaction mixture was stirred at room temperature for half an hour, amine (1.2 equivalent, 0.12 mmol) was added and the reaction mixture was stirred at room temperature for 2-3 hour. Reverse phase HPLC was used to purify the final compound.

후처리

  1. stirringthe reaction mixture was stirred at room temperature for 2-3 hour
  2. customto purify the final compound

출처 및 근거

ORD 기록
ord-f2310ed1b88740c2b2f637a35f217648
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921376B2

반응 노트

불러오는 중…