Potassium Carbonate → HCID 58897002, 화합물

HRID 1409118노트

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HRID 1409118 반응식
BrC1C([Cl:8])=CN=C2NC=CC=12.[C:12]1([CH3:38])[CH:17]=[CH:16][C:15]([S:18]([N:21]2[C:25]3=[N:26][CH:27]=[CH:28][C:29]([C:30]4[CH:31]=[C:32]([CH2:36]O)[CH:33]=[CH:34][CH:35]=4)=[C:24]3[CH:23]=[CH:22]2)(=[O:20])=[O:19])=[CH:14][CH:13]=1.C([O-])([O-])=O.[K+].[K+].O1CCOCC1>C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Pd].O>[Cl:8][CH2:36][C:32]1[CH:31]=[C:30]([C:29]2[CH:28]=[CH:27][N:26]=[C:25]3[N:21]([S:18]([C:15]4[CH:16]=[CH:17][C:12]([CH3:38])=[CH:13][CH:14]=4)(=[O:20])=[O:19])[CH:22]=[CH:23][C:24]=23)[CH:35]=[CH:34][CH:33]=1

참가 물질

7

반응물 4

HCID 11430Potassium CarbonateHCID 312751,4-DioxaneHCID 468355224-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridineHCID 58896939HCID 58896939, 화합물

생성물 1

HCID 58897002HCID 58897002, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 11979704Tetrakis(triphenylphosphine)palladium용매

실험 절차

Under N2, Compound D (1.95 g, 8.49 mmol) and compound G′ (1.1 equivalent, 9.34 mmol) and K2CO3 (3.3 equivalent, 28 mmol) were dissolved into 9 mL of dioxane and 3 mL of H2O in a microwave, to this reaction mixture, catalytic amount of Pd(Pph3)4 was added and the tube was under microwave irradiation at 170° C. for 10 min. After cooled down the reaction mixture, the product crashed out and filtered off the solid, washed with H2O and CH3CN respectively to obtain title compound H′ quantitatively. MS+1=430.5.

후처리

  1. additionwas added
  2. customthe tube was under microwave irradiation at 170° C. for 10 min
  3. temperatureAfter cooled down the reaction mixture
  4. filtrationfiltered off the solid
  5. washwashed with H2O and CH3CN respectively

출처 및 근거

ORD 기록
ord-5429da1a8918421fb5b6abde8865d958
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921376B2

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