Methanol → 3-[5-(3-Methoxy-3-oxopropyl)-1,3-oxazol-2-yl]benzoic acid

HRID 14092노트

반응식

HRID 14092 반응식
[C:1]([CH2:4][CH2:5][C:6]1[O:10][C:9]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([OH:16])=[O:15])=[N:8][CH:7]=1)([OH:3])=[O:2].S(Cl)(Cl)=O.[CH3:24]O>>[CH3:24][O:2][C:1](=[O:3])[CH2:4][CH2:5][C:6]1[O:10][C:9]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([OH:16])=[O:15])=[N:8][CH:7]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 210856903-[5-(2-Carboxyethyl)-1,3-oxazol-2-yl]benzoic acid

생성물 1

HCID 210856913-[5-(3-Methoxy-3-oxopropyl)-1,3-oxazol-2-yl]benzoic acid

실험 절차

To 3-[5-(2-carboxyethyl)-1,3-oxazol-2-yl]benzoic acid (317 mg, 1.2 mmol) in methanol (5 mL) is added thionyl chloride (4.4 μL, 0.06 mmol), and the reaction is stirred at room temperature 16 h. The solution is concentrated under reduced pressure to give the title compound. ESI MS m/z 274.1 [M−H]−.

후처리

  1. concentrationThe solution is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-aefa3b74c30b479da2d952052a0e8df6
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

반응 노트

불러오는 중…