Cyclopropylamine → HCID 70980010, 화합물

HRID 1409381

반응식

HRID 1409381 반응식
[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]([OH:13])=O)[O:8][N:7]=1)=[O:5])[CH3:2].[CH:14]1([NH2:17])[CH2:16][CH2:15]1>C(Cl)Cl>[CH:14]1([NH:17][C:11]([C:9]2[O:8][N:7]=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:10]=2)=[O:13])[CH2:16][CH2:15]1

참가 물질

4

반응물 2

HCID 69828CyclopropylamineHCID 216484863-Ethyl 3,5-isoxazoledicarboxylate

생성물 1

HCID 70980010HCID 70980010, 화합물수율 43.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

The title compound was prepared starting from 3-(ethoxycarbonyl)isoxazole-5-carboxylic acid (3.78 mmol, 0.7 g) and cyclopropyl-amine (2.91 mmol, 0.166 g) using DCM (10 ml) as the solvent. The mixture was diluted with DCM and washed with 1 M Na2CO3 and water. The organic phase was dried, filtered and evaporated. The crude product was purified by flash chromatography. 0.284 g of the title compound was obtained. 1H-NMR (400 MHz, DMSO-d6) δ 0.58-0.64 (m, 2H), 0.70-0.77 (m, 2H), 1.33 (t, 3H), 2.80-2.90 (m, 1H), 4.38 (q, 2H), 7.39 (s, 1H), 9.04 (bs, 1H).

후처리

  1. customThe title compound was prepared
  2. washwashed with 1 M Na2CO3 and water
  3. customThe organic phase was dried
  4. filtrationfiltered
  5. customevaporated
  6. customThe crude product was purified by flash chromatography

출처 및 근거

ORD 기록
ord-fa272f1e318e47bf82578e78ce2619ae
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921378B2

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