Potassium Carbonate → HCID 65369304, 화합물

HRID 1409524노트

반응식

HRID 1409524 반응식
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:15]([O:17][CH2:18]Cl)[CH3:16]>CC(C)=O>[Br:1][C:2]1[C:7]([O:8][CH2:18][O:17][CH2:15][CH3:16])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 18523Chloromethyl ethyl etherHCID 230702-Bromo-3-pyridinol

생성물 1

HCID 65369304HCID 65369304, 화합물수율 88.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a RBF was added 2-bromo-3-pyridinol (6.0 g, 34.5 mmol) and potassium carbonate (11.91 g, 86 mmol) in Acetone (50 mL). The suspension was stirred at ambient temperature for 30 min and then treated with the drop-wise addition of chloromethyl ethyl ether (3.34 mL, 36.7 mmol) via addition funnel. The mixture was stirred at ambient temperature overnight. The mixture was filtered and the filtrate partitioned between EtOAc and water. The combined organic layers were washed with water, saturated solution of sodium bicarbonate and brine, then dried over Mg2SO4 to afford 7.12 g of desired product as a clear oil which was used without further purification.

후처리

  1. stirringThe mixture was stirred at ambient temperature overnight
  2. filtrationThe mixture was filtered
  3. customthe filtrate partitioned between EtOAc and water
  4. washThe combined organic layers were washed with water, saturated solution of sodium bicarbonate and brine
  5. dry with materialdried over Mg2SO4

출처 및 근거

ORD 기록
ord-78edc630e1644e4796a4b93a67eaea36
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921363B2

반응 노트

불러오는 중…