Piperidin-4-ol → HCID 67608386, 화합물
반응식
Br[C:2]1[CH:7]=[N:6][C:5]([CH2:8][CH3:9])=[CH:4][N:3]=1.[OH:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>C(O)(C)C>[CH2:8]([C:5]1[N:6]=[CH:7][C:2]([N:14]2[CH2:15][CH2:16][CH:11]([OH:10])[CH2:12][CH2:13]2)=[N:3][CH:4]=1)[CH3:9]참가 물질
4
반응 조건
- 온도
- 150 °C
실험 절차
A mixture of 2-bromo-5-ethyl-pyrazine (1.66 g) and 4-hydroxy-piperidine (2.24 g) in isopropanol (15 mL) is heated in an autoclave to 150° C. over night. The solvent is evaporated in vacuo and the residue is mixed with water and dichloromethane. The aqueous phase is extracted with dichloromethane and the combined organic phases are washed with brine, dried over MgSO4, and concentrated in vacuo to give the title compound. LC (method 7): tR=0.66 min; Mass spectrum (ESI+): m/z=208 [M+H]+.
후처리
- customThe solvent is evaporated in vacuo
- additionthe residue is mixed with water and dichloromethane
- extractionThe aqueous phase is extracted with dichloromethane
- washthe combined organic phases are washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-8c0cd69fc6694b87b330ad5fb6e42c0e
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08921398B2
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