Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dichloropyrimidine → (3S,4R)-1-(5-chloropyrimidin-2-yl)-N-cyclopropyl-3-fluoropiperidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dichloropyrimidine | HCID 590641 | — |
| 반응물 | tert-butyl N-cyclopropyl-N-[(3S,4R)-3-fluoropiperidin-4-yl]carbamate | HCID 68290240 | — |
| 생성물 | (3S,4R)-1-(5-chloropyrimidin-2-yl)-N-cyclopropyl-3-fluoropiperidin-4-amine | HCID 71093748 | — |
반응 단계
The title compound is prepared from tert-butyl N-cyclopropyl-N-[(3S,4R)-3-fluoropiperidin-4-yl]carbamate and 2,5-dichloropyrimidine following a procedure analogous to that described for Intermediate 87. LC (method 20): tR=1.86 min; Mass spectrum (APCI): m/z=271 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08921398B2 |
| 출처 데이터셋 | uspto-grants-2014_12 |
| ORD ID | ord-1c301df210d54958949cb8a1ab2289d7 |
| 출처 메모 | uspto-grants-2014_12 |