2-Chloro-5-(trifluoromethyl)pyrimidine → HCID 71112316, 화합물

HRID 1409749

반응식

HRID 1409749 반응식
[CH:1]1([N:4]([C@@H:12]2[CH2:17][CH2:16][NH:15][CH2:14][C@@H:13]2[F:18])C(=O)OC(C)(C)C)[CH2:3][CH2:2]1.Cl[C:20]1[N:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][N:21]=1>>[CH:1]1([NH:4][C@@H:12]2[CH2:17][CH2:16][N:15]([C:20]3[N:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][N:21]=3)[CH2:14][C@@H:13]2[F:18])[CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 133170192-Chloro-5-(trifluoromethyl)pyrimidineHCID 68290240tert-butyl N-cyclopropyl-N-[(3S,4R)-3-fluoropiperidin-4-yl]carbamate

생성물 1

HCID 71112316HCID 71112316, 화합물

실험 절차

The title compound is prepared from tert-butyl N-cyclopropyl-N-[(3S,4R)-3-fluoropiperidin-4-yl]carbamate and 2-chloro-5-trifluoromethyl-pyrimidine following a procedure analogous to that described for Intermediate 87.

출처 및 근거

ORD 기록
ord-55f19808c66842e7ac26abdcb487ed41
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921398B2

연결된 노트

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