Isovaleric Acid → HCID 178447385, 화합물

반응식

Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[CH3:27][CH:28]([CH3:33])[CH2:29][C:30](O)=[O:31]>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:30](=[O:31])[CH2:29][CH:28]([CH3:33])[CH3:27])[CH2:24][CH2:25]2)=[CH:4]1

참가 물질

반응물 2

HCID 10430Isovaleric Acid

HCID 178478713HCID 178478713, 화합물2회

생성물 1

HCID 178447385HCID 178447385, 화합물

실험 절차

The title compound, off-white solid (74 mg, 72%), MS (ISP) m/z=411.5 [(M+H)+], mp 182° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and 3-methyl-butyric acid.

출처 및 근거

ORD 기록: ord-76fd0d2e88bf45cdbd4c627052e3728a
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08921397B2

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