4-(Trifluoromethyl)piperidine-1-carbonyl chloride → 6-Chlorobenzo[d]isoxazol-3-yl 4-trifluoromethylpiperidine-1-carboxylate

반응식

[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6]([OH:9])=[N:7][O:8][C:4]=2[CH:3]=1.[F:12][C:13]([F:24])([F:23])[CH:14]1[CH2:19][CH2:18][N:17]([C:20](Cl)=[O:21])[CH2:16][CH2:15]1>>[F:23][C:13]([F:12])([F:24])[CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:9][C:6]2[C:5]3[CH:10]=[CH:11][C:2]([Cl:1])=[CH:3][C:4]=3[O:8][N:7]=2)=[O:21])[CH2:16][CH2:15]1

참가 물질

반응물 2

HCID 798870814-(Trifluoromethyl)piperidine-1-carbonyl chloride

HCID 178518989HCID 178518989, 화합물

생성물 1

HCID 118577526-Chlorobenzo[d]isoxazol-3-yl 4-trifluoromethylpiperidine-1-carboxylate

실험 절차

In analogy to example 1,200 mg (1.18 mmol) of 6-chlorobenzo[d]isoxazol-3-ol were reacted with 305 mg (1.41 mmol) of 4-trifluoromethylpiperidine-1-carbonyl chloride. Yield: 229 mg (56%), M+H+: 349.05.

출처 및 근거

ORD 기록: ord-5a9899811901403280f4b4e14efd6544
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08921404B2

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