2H,3H-[1,2]thiazolo[5,4-b]pyridin-3-one → HCID 69228848, 화합물

반응식

[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3](=[O:10])[NH:2]1.[CH3:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18](Cl)=[O:19])[CH2:14][CH2:13]1>>[CH3:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:10][C:3]2[C:4]3[C:5](=[N:6][CH:7]=[CH:8][CH:9]=3)[S:1][N:2]=2)=[O:19])[CH2:14][CH2:13]1

참가 물질

반응물 2

HCID 27275632H,3H-[1,2]thiazolo[5,4-b]pyridin-3-one

HCID 152215164-Methylpiperidine-1-carbonyl Chloride

생성물 1

HCID 69228848HCID 69228848, 화합물

실험 절차

In analogy to example 1, 60 mg (0.4 mmol) of isothiazolo[5,4-b]pyridin-3-one were reacted with 76 mg (0.47 mmol) of 4-methylpiperidine-1-carbonyl chloride. Yield: 29 mg (27%), M+H+: 278.13.

출처 및 근거

ORD 기록: ord-0f348c81326c4ae590d9b7386bd604f7
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08921404B2

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