2-(Methoxymethyl)-1-(3-nitrophenyl)pyrrolidine → 3-(2-(Methoxymethyl)pyrrolidin-1-yl)aniline

HRID 1410049

반응식

HRID 1410049 반응식
[CH3:1][O:2][CH2:3][CH:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=1>CO.[Pd]>[CH3:1][O:2][CH2:3][CH:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=1)[NH2:15]

참가 물질

4

반응물 1

HCID 683792402-(Methoxymethyl)-1-(3-nitrophenyl)pyrrolidine

생성물 1

HCID 683793313-(2-(Methoxymethyl)pyrrolidin-1-yl)aniline수율 97%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The mixture of 2-(methoxymethyl)-1-(3-nitrophenyl)pyrrolidine (200 mg, 0.85 mmol), Pd/C (50 mg, 10%) in 50 mL of MeOH was stirred at room temperature for 18 hours under H2 atmosphere. Pd/C was filtrated off and the filtrate was concentrated under reduce pressure to give crude 3-(2-(methoxymethyl)pyrrolidin-1-yl)aniline (170 mg) as an oil. LC-MS: 207 [M+H]+, tR=1.15 min.

후처리

  1. filtrationPd/C was filtrated off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-522aa5c99bb349a4b7ff8428aab15cf4
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921383B2

연결된 노트

불러오는 중…