4-Bromoaniline → N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamide

HRID 1410227노트

반응식

HRID 1410227 반응식
[F:1][CH:2]([F:19])[CH2:3][O:4][C:5]1[CH:13]=[C:12]([NH:14][CH3:15])[C:11]([N+:16]([O-:18])=[O:17])=[CH:10][C:6]=1[C:7]([OH:9])=O.[Br:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][CH:22]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C>[Br:20][C:21]1[CH:27]=[CH:26][C:24]([NH:25][C:7](=[O:9])[C:6]2[CH:10]=[C:11]([N+:16]([O-:18])=[O:17])[C:12]([NH:14][CH3:15])=[CH:13][C:5]=2[O:4][CH2:3][CH:2]([F:1])[F:19])=[CH:23][CH:22]=1

참가 물질

5

반응물 3

HCID 78074-BromoanilineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 595298542-(2,2-Difluoroethoxy)-4-(methylamino)-5-nitrobenzoic acid

생성물 1

HCID 59529852N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The sub-title compound was prepared in accordance with Example 72, step (c) using 2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzoic acid (800 mg; 2.90 mmol), 4-bromoaniline (499 mg; 2.90 mmol), HBTU (1.10 g; 2.90 mmol), TEA (587 mg; 5.80 mmol) and DMF (15 mL). Yield: 1.01 g (81%).

출처 및 근거

ORD 기록
ord-3e98a095978440038ad997a9b8de99e7
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921405B2

반응 노트

불러오는 중…